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Next Generation Sequencing: Upcoming Trends and Technologies

Mar 19, 2018

DNA sequencing has enhanced the capabilities of research labs and medical professionals to investigate various disease and genetic illnesses. Mutations are usually initiated by faulty genetic sequencing and leads to various genetic conditions and diseases such as cancer. As a result, DNA sequencing provides convenient information in developing an appropriate treatment. However, it is a very expensive process and requires machines capable of handling large volumes of data. Next Generation Sequencing (NGS) technology is used for sequencing millions of small DNA fragments simultaneously. Next generation sequencing technology helps in rapidly sequencing large stretches of DNA base pairs spread over entire genomes, by using the help of highly sophisticated instruments, which are capable of producing hundreds of gigabytes of data in a single sequencing run. Next generation sequencing finds application in whole-genome, exome, and transcriptome sequencing. The recent procurement market intelligence report from SpendEdge on the global next generation sequencing market forecasts a market growth rate of 18.73%, owing to the reduction in the cost of genome sequencing methods.

Request Free SampleTrends in the next generation sequencing market

Genome library automation with barcode scanning

The recent development in technologies has enabled companies to produce sequencing in a single day at the cost of about $15 per sample. Genome library automation includes the incorporation of LIMS that is used to provide tracking mechanisms during the sample preparation and incorporation of barcodes to the micro RNA libraries at the PCR step. It results in effective delivery of target and whole genome data for thousands of samples at a reasonable cost. Additionally, it helps buyers to achieve a rate of almost 50 libraries capture every day by scanning the micro RNA barcode.

Adoption and integration of advanced LIMS real-time tracking methods

Laboratory information management system (LIMS) tracking has enabled next generation sequencing equipment to effectively deliver whole genome sequencing by producing an accurate real-time digital count of sequence representation. As a result, it allows labs to monitor the data in real-time. Additionally, such tracking mechanism helps buyers to identify variations in the copy number and aids in mapping large deletions.

Adoption of real-time PCR systems

Real-time PCR systems can precisely deliver quantitative real-time PCR results for a variety of genomic research applications. The system provides real-time polymerase chain reaction monitoring for gene expression quantification, analysis, and genotyping, which uses allelic discrimination or high-resolution melting. The latest version of the software’s can collect melt curve data for high-resolution melt (HRM) applications and provides the option to export in Real-time PCR Data Markup Language (RDML) for compatibility with MIQE guidelines.

Increased adoption of high-throughput multiplexing technology

As we enter the post-genome sequencing era, efficient technologies are required to sift through the enormous amount of genetic information. High throughput sequencing offers numerous advantages over other sequencing methods, such as multiplexing several genetic samples in one run. Additionally,  it uses a paired-end sequencing method, which reduces running costs and operating time per experiment. It also provides simplified analysis of the sample with the help of automatic sample identification.

Adoption of low input DNA sampling methods

Low input DNA sampling methods are effective in conducting studies when limited DNA is available. Such a process also preserves the DNA for future uses, which can be suitable in archeology and ancient DNA studies. Such a method also helps to decrease the operational costs by reducing the amount of reagent required to run the experiment.

Use of FFPE samples and liquid biopsies

Buyers are increasingly procuring FFPE samples instead of conventional methods. Its use has helped to gain results in translational medicine, which has been applied into modern clinical practice. As a result, the US FDA has approved new therapies that use this method for targeting mutated genes, resulting in an increased demand for such equipment. Additionally, such methods are helping clinicians to enhance patient care by analyzing the data.

To get more information on the trends in the next generation sequencing market along with supply market insights, procurement best practices, pricing insights, and supplier selection criteria in SpendEdge’s upcoming report on the global next generation sequencing market.

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